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apalutamide will minimize the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicines which have been CYP3A4 substrates can result in lessen exposure to these remedies.To watch formulary info 1st generate an